Helicobacter pyloridefines local immune response through interaction with dendritic cells
نویسندگان
چکیده
منابع مشابه
Local Immune Response in Helicobacter pylori Infection
There have been few studies concerning the cytokine profiles in gastric mucosa of Helicobacter pylori-infected patients with normal mucosa, chronic gastritis, and gastric carcinoma (GAC).In the present study, we aimed to elucidate the genomic expression levels and immune pathological roles of cytokines-interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-4, IL-6, IL-10, transform...
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Dendritic cells (DCs) induce pathogen-specific T cell responses. We comprehensively studied the effects of addition of maturation stimulus, fibroblasts (fibroblast conditioned medium), PHA activated T cells (T cell conditioned medium), and mixture of fibroblast & PHA activated T cells (FCM-TCCM) conditioned media on maturation of DCs. Monocytes were cultured with GM-CSF and IL-4 for five days. ...
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The study of dendritic cells (DCs) has seen a rapid expansion in recent years, and their importance within the immune system is now widely recognized. Along with B lymphocytes and mononuclear phagocytes, DCs make up what are known as the professional antigen-presenting cells (APCs). These are cells which are capable of highly efficiently presenting antigens to the immune system in the context o...
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Host cell interactions with bacterial pathogens trigger a wide variety of complex cellular signaling pathways that ultimately determine disease outcome. These inflammatory signaling cascades can often be traced back to specific virulence factors within the pathogen, which interact with unique host cells that come in contact with the invading organism. Ex vivo model systems which recapitulate th...
متن کاملInhibition of cathepsin X enzyme influences the immune response of THP-1 cells and dendritic cells infected with Helicobacter pylori
BACKGROUND The immune response to Helicobacter pylori importantly determines the outcome of infection as well as the success of eradication therapy. We demonstrate the role of a cysteine protease cathepsin X in the immune response to H. pylori infection. MATERIALS AND METHODS We analysed how the inhibition of cathepsin X influenced the immune response in experiments when THP-1 cells or dendri...
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ژورنال
عنوان ژورنال: FEMS Immunology & Medical Microbiology
سال: 2011
ISSN: 0928-8244,1574-695X
DOI: 10.1111/j.1574-695x.2010.00761.x